Clinton, 34, daughter of former President Bill Clinton and former Secretary of State Hillary Rodham Clinton, told Fast Company that she has always denied any interest in running for office.
"The answer was just a visceral no," she said. "Not because I had made any conscientious, deliberate decision, but since people had been asking for as long as literally I could remember, it was no."
Besides, said Clinton, a Manhattan resident, "I live in a city and a state and a country where I support my elected representatives."
But she said that if she became dissatisfied with "my mayor or my city councilwoman or my congresswoman or either of my senators" she might have to rethink the question of going into politics.
"Maybe then I'd have to ask and answer the question for myself, and come to a different answer," she said.