Kerry will meet with Russian President Vladimir Putin and Foreign Minister Sergey Lavrov.
Their conversations will also touch on a host of bilateral tensions between Washington and Moscow.
They include the Kremlin's halt on U.S. adoptions of Russian children and new Russian restrictions on civil society groups.
And the talks will definitely address the ethnic Chechen brothers suspected of killing three people and injuring over 200 in Boston earlier this month.
Kerry told reporters Tuesday his upcoming trip to Russia is "overdue."